Abstract

Mounting evidence supports the potential of dietary bioactives to reduce chronic disease risk. N-trans-caffeoyltyramine (NCT) and N-trans-feruloyltyramine (NFT) have been hypothesized to drive regulation of gut permeability, but these components have not yet been studied in the context of the human gut microbiome. This work examined whether purified NCT and NFT, or a hemp hull product containing NCT and NFT (Brightseed® Bio Gut Fiber™), can impact the gut microbiome using an in vitro fermentation assay. Representative human gut microbiomes were treated with Bio Gut Fiber™ or NCT and NFT and compared to starch and methylcellulose, as controls, in vitro. Stronger changes were exerted by Bio Gut Fiber™, NCT, and NFT. Communities treated with Bio Gut Fiber™ saw increased productivity and diversity. We found a dose-dependent effect of NCT and NFT on microbial communities. Here, we describe novel potential for hemp-derived bioactives to shape the gut microbiome.

Karla E. Flores Martinez, Clay S. Bloszies, Matthew J. Bolino, Bethany M. Henrick, and Steven A. Frese 2024, Hemp hull fiber and two constituent compounds, N-trans-caffeoyltyramine and N-trans-feruloyltyramine, shape the human gut microbiome in vitro, Food Chemistry: X, Volume 23, 30 October 2024, 101611

Visit Journal referenced web page

Extension Associated Contacts

Steven Frese

Also of Interest:


Industrial Fiber Hemp: An Early Initiative to Capture Varietal Response in Nevada J. Solomon, A. Ogunleye, A. Opoku, F. Barrios-Masias, S. Huber, S. Foster 2022, Extension, University of Nevada, Reno, FS-22-11
Banana Berry Spread on Tortilla Did you know a banana contains fiber, potassium, folate, and antioxidants, such as vitamin C? All of these support heart health. A medium-sized banana (about 7 inches long) contains 3 grams of fiber. Weding, H. 2024, Extension \| University of Nevada, Reno, Recipes
Forage Production Performance of Winter Small Grains in Western Nevada Solomon, J.K.Q., Opoku, A., Huber, S., and McCuin, G. 2025, Extension, University of Nevada, Reno, FS-25-04
Chocolate Squash Cake Adding squash into a chocolate cake adds flavor plus fiber, vitamin K, phosphorus, and folate. Mazzullo, N. 2025, Extension \| University of Nevada, Reno, Recipes
Greek Yogurt Oatmeal A breakfast rich in fiber, protein and dairy. Extension's Healthy Aging Program 2021, Extension, University of Nevada, Reno, Newsletter - Healthy LIVING while aging! (2021-03)

Hemp hull fiber and two constituent compounds, N-trans-caffeoyltyramine and N-trans-feruloyltyramine, shape the human gut microbiome in vitro

Abstract

Published by: Karla E. Flores Martinez, Clay S. Bloszies, Matthew J. Bolino, Bethany M. Henrick, and Steven A. Frese, 2024, Hemp hull fiber and two constituent compounds, N-trans-caffeoyltyramine and N-trans-feruloyltyramine, shape the human gut microbiome in vitro, Food Chemistry: X, Volume 23, 30 October 2024, 101611