Meet Zandawala

Photo of Meet Zandawala, Extension

Meet Zandawala

Assistant Professor

Summary

Our research group is interested in context-dependent modulation of behaviors and physiological processes by neuropeptides and their G-protein coupled receptors.

The nervous systems of animals utilize a wide variety of chemicals for neuronal communication. These include amino acids, biogenic amines, and neuropeptides amongst others. Neuropeptides are by far the most diverse, and control a range of essential physiological processes including feeding, metabolism, sleep, stress, reproduction, development and locomotion. Our working group is interested in understanding how neuropeptides mediate their effects in the fruit fly Drosophila melanogaster. We utilize multiple approaches in our lab including standard molecular techniques, CRISPR/Cas9, Drosophila genetics, behavioral analyses, optogenetics and calcium imaging. We are also developing cutting-edge genetic tools to study neuropeptide function in Drosophila.  

News & Journal Articles, Fact Sheets, Reports...

Journals
The neuropeptide pigment-dispersing factor signals independently of Bruchpilot-labelled active zones in daily remodelled terminals of Drosophila clock neurons Benedikt Hofbauer, Meet Zandawala, Nils Reinhard, Dirk Rieger, Christian Werner, Jan Felix Evers and Christian Wegener 2024, European Journal of Neuroscience
Anti-diuretic hormone ITP signals via a guanylate cyclase receptor to modulate systemic homeostasis in Drosophila
This important study provides a comprehensive analysis of ITP neuropeptide and its role as an anti-diuretic and metabolic hormone in the fruit fly Drosophila.
Jayati Gera, Marishia Agard, Hannah Nave, Farwa Sajadi, Leena Thorat, Shu Kondo, Dick R. Nässel, Jean-Paul V. Paluzzi and Meet Zandawala 2024, eLife
Another fly diuretic hormone: tachykinins increase fluid and ion transport by adult Drosophila melanogaster Malpighian ‘renal’ tubules Marishia Agard, Meet Zandawala and Jean-Paul Paluzzi 2024, Journal of Experimental Biology
Aminergic and peptidergic modulation of Insulin-Producing Cells in Drosophila Martina Held, Rituja S. Bisen, Meet Zandawala, Alexander S. Chockley, Isabella S. Balles, Selina Hilpert, Sander Liessem, Federico Cascino-Milani and Jan M. Ache 2024, eLife
Proteome-wide neuropeptide identification using NeuroPeptide-HMMer (NP-HMMer) Meet Zandawala, Muhammad Bilal Amir, Joel Shin, Won Cheol Yim and Luis Alfonso Yáñez-Guerra 2024, General and Comparative Endocrinology
Whole-brain annotation and multi-connectome cell typing of Drosophila Philipp Schlegel, Yijie Yin, Alexander S. Bates, Sven Dorkenwald, Katharina Eichler, Paul Brooks, Daniel S. Han, Marina Gkantia, Marcia dos Santos, Eva J. Munnelly, Griffin Badalamente, Laia Serratosa Capdevila, Varun A. Sane, Alexandra M. C. Fragniere, Ladann Kiassat, Markus W. Pleijzier, Tomke Stürner, Imaan F. M. Tamimi, Christopher R. Dunne, Irene Salgarella, Alexandre Javier, Siqi Fang, Eric Perlman, Tom Kazimiers, Sridhar R. Jagannathan, Arie Matsliah, Amy R. Sterling, Szi-chieh Yu, Claire 2024, Nature
Neuronal wiring diagram of an adult brain Sven Dorkenwald, Arie Matsliah, Amy R. Sterling, Philipp Schlegel, Szi-chieh Yu, Claire E. McKellar, Albert Lin, Marta Costa, Katharina Eichler, Yijie Yin, Will Silversmith, Casey Schneider-Mizell, Chris S. Jordan, Derrick Brittain, Akhilesh Halageri, Kai Kuehner, Oluwaseun Ogedengbe, Ryan Morey, Jay Gager, Krzysztof Kruk, Eric Perlman, Runzhe Yang, David Deutsch, Doug Bland, Marissa Sorek, Ran Lu, Thomas Macrina, Kisuk Lee, J. Alexander Bae, Shang Mu, Barak Nehoran, Eric Mitchell, Sergiy Popovy 2024, Nature
Characterization of clock-related proteins and neuropeptides in Drosophila littoralis and their putative role in diapause Giulia Manoli, Meet Zandawala, Taishi Yoshii and Charlotte Helfrich-Förster 2023, Journal of Comparative Neurology
Discovery of Paralogous GnRH and Corazonin Signaling Systems in an Invertebrate Chordate Luis Alfonso Yañez Guerra and Meet Zandawala 2023, Genome Biology and Evolution, Volume 15, Issue 7, July 2023, evad108
Receptor deorphanization in an echinoderm reveals kisspeptin evolution and relationship with (SALMFamide) neuropeptides Nayeli Escudero Castelán, Dean C. Semmens, Luis Alfonso Yañez Guerra, Meet Zandawala, Mario dos Reis, Susan E. Slade, James H. Scrivens, Cleidiane G. Zampronio, Alexandra M. Jones, Olivier Mirabeau and Maurice R. Elphick 2022, BMC Biol (2022). 20(1) 187
A neuroendocrine pathway modulating osmotic stress in Drosophila Meet Zandawala, Thomas Nguyen, Marta Balanyà Segura, Helena A. D. Johard, Mirjam Amcoff, Christian Wegener, Jean-Paul Paluzzi and Dick R. Nässel 2021, PLOS Genetics (2021). 17(3) 1–31
Characterization of a set of abdominal neuroendocrine cells that regulate stress physiology using colocalized diuretic peptides in Drosophila Meet Zandawala, Richard Marley, Shireen A. Davies and Dick R. Nässel 2018, Cellular and Molecular Life Sciences (2018). 75(6) 1099–1115.
Discovery of novel representatives of bilaterian neuropeptide families and reconstruction of neuropeptide precursor evolution in ophiuroid echinoderms Meet Zandawala, Ismail Moghul, Luis Alfonso Yañez Guerra, Jérôme Delroisse, Nikara Abylkassimova, Andrew F. Hugall, Timothy D. O'Hara and Maurice R. Elphick 2017, Open Biology 7(9) 170129
Modulation of Drosophila post-feeding physiology and behavior by the neuropeptide leucokinin Meet Zandawala, Maria E. Yurgel, Michael J. Texada, Sifang Liao, Kim F. Rewitz, Alex C. Keene and Dick R. Nässel 2017, in PLOS Genetics (2018). 14(11) 1–31
Reviews
Leptin- and cytokine-like unpaired signaling in Drosophila
This review focuses on the unpaired family of proteins in Drosophila which are evolutionarily related to mammalian leptin and the cytokine interleukin 6.
Meet Zandawala and Jayati Gera 2024, Molecular and Cellular Endocrinology
Endocrine cybernetics: neuropeptides as molecular switches in behavioural decisions Dick R. Nässel and Meet Zandawala 2022, Open Biol (2022). 12(7) 220174.
Hormonal axes in Drosophila: regulation of hormone release and multiplicity of actions Dick R. Nässel and Meet Zandawala 2020, Cell and Tissue Research 382
Tachykinins: Neuropeptides That Are Ancient, Diverse, Widespread and Functionally Pleiotropico in Frontiers Dick R. Nässel, Meet Zandawala, Tsuyoshi Kawada and Honoo Satake 2019, Neuroscience (2019). 13 1262
The evolution and nomenclature of GnRH-type and corazonin-type neuropeptide signaling systems. Meet Zandawala, Shi Tian and Maurice R. Elphick 2018, General and comparative endocrinology (2018). 264 64–77