Implications

• Evidence suggests that microRNAs derived from animal-based foods may survive digestion and be absorbed by intestinal cells, potentially influencing host gene expression and metabolic regulation.
• Dietary microRNAs’ absorption and biological activity open new perspectives in nutrigenomics, highlighting how food components can modulate transcriptomic and metabolic responses in consumers.
• Understanding how animal nutrition affects tissue-specific microRNA expression supports the development of feeding strategies and gene-editing approaches to optimize both nutrient composition and bioactive RNA content in meat.
• The dual influence of diet and molecular regulation offers a pathway toward producing animal-derived foods with enhanced health-promoting properties while improving animal performance and product quality.